Clinical Mass Spectrometry
Stable isotope-labeled standards supporting mass spectrometry across clinical diagnostics
Clinical laboratory medicine has evolved and diversified over the past few decades. Although the field has seen major advancements (in terms of methodology, instrumentation, informatics, and automation) and transitions (away from conventional immunoassays), mass spectrometry (MS) is now utilized across several areas of diagnostics. This encompasses therapeutic drug monitoring, toxicology, and endocrinology testing, among other areas of screening.
Toxicology
Endocrinology
Mass spectrometry (MS) is a fundamental and versatile technique for such analyte measurements due to its sensitivity, specificity, throughput, and multiplexicity. Stable isotope-labeled standards are integral to this analysis.
🔬 Researcher Perspective: the SILK™ assay
Joel Braunstein, MD, and Tim West, PhD (C2N Diagnostics) describe the stable isotope labeling kinetic (SILK™) assay, developed to measure blood-derived protein biomarkers such as α-β isoforms, used in the study and progression tracking of Alzheimer's disease. The assay relies on 13C6-leucine, an essential amino acid that readily crosses the blood-brain barrier, to trace the production and clearance of these proteins in plasma and cerebrospinal fluid.
Eurisotop is proud to offer a variety of analytical standards for identification/quantification in clinical MS samples. These standards are highly characterized for analytical purposes, suitable for use in a variety of sample types, and available in various packaging sizes and formats.
