Clinical laboratory medicine has evolved and diversified over the past few decades. Although the field has seen major advancements (in terms of methodology, instrumentation, informatics, and automation) and transitions (away from conventional immunoassays), mass spectrometry (MS) is now utilized across several areas of diagnostics. This encompasses therapeutic drug monitoring, toxicology, and endocrinology testing, among other areas of screening.
Mass spectrometry (MS) is a fundamental and versatile technique for such analyte measurements due to its sensitivity, specificity, throughput, and multiplexicity. Stable isotope-labeled standards are integral to this analysis, as noted by the references below. Another example of clinical mass spectrometry is the work described in the Researcher Perspective from Joel Braunstein, MD, and Tim West, PhD (C2N Diagnostics). They provide an overview of the stable isotope labeling kinetic (SILK™) assay developed to measure blood-derived protein biomarkers, such as α-β isoforms, involved in the study of Alzheimer‘s disease and to track its progression.
Eurisotop is proud to offer a variety of analytical standards for identification/quantification in clinical MS samples. These standards are highly characterized for analytical purposes, suitable for use in a variety of sample types, and available in various packaging sizes and formats.