Metabolic Research

Isotope-dilution mass spectrometry (IDMS) is inarguably the most accurate, sensitive, reproducible and popular method available for quantifying small and intermediate-sized molecules in a wide range of sample types. One primary reason why compounds enriched in stable isotopes make ideal internal standards for comparative or absolute quantitation using mass spectrometry is that separate signals from the "heavy" (isotope enriched) and "light" (native) forms of the same compound are detected simultaneously.

¹³C, ¹⁵N and ¹⁷O nuclei are NMR active, and thus compounds enriched in these isotopes allow for magnetic resonance detection. The large chemical shift range and favorable relaxation properties of the ¹³C nucleus has made ¹³C-enriched substrates highly valuable probes of cellular chemistry and metabolism, particularly in the rapidly advancing field of hyperpolarization.

Euriso-Top recognizes the importance of high chemical purity and isotopic enrichment for metabolic studies. For this reason, all products are tested to meet high specifications for both. All products are shipped with a Certificate of Analysis that indicates the passing results and an MSDS to describe the product even further. We may be able to provide additional data upon request.