Deuterated Reagents for Pharmaceuticals
In recent years, some pharmaceutical companies have begun to investigate deuteration of molecules that may provide advantages over their existing nondeuterated counterparts. In addition, increasing research into the potential medical advantages of new deuterated drugs is also occurring.
Stable isotope-labeled synthetic intermediates
The potential advantages of deuterated pharmaceuticals include:
🔬 Improved metabolic profile
May potentially reduce or eliminate unwanted side effects or undesirable drug interactions.
💊 Improved oral bioavailability
Deuteration in some compounds has reduced the presystemic metabolism that occurs in the digestive tract, allowing more of the unmetabolized drug to reach its target.
⌛ Increased half-life
Deuterated compounds can have a slower pharmacokinetic effect, extending absorption and distribution, potentially reducing the number of doses required.
Catalog
| Catalog no. | Description |
|---|---|
| DLM-112 | Acetaldehyde-d (D, 99%) |
| DLM-12RG* | Acetic acid-d4 (D, 99%) |
| DLM-1556 | Acetic acid-d (D, 98%) |
| DLM-1162 | Acetic anhydride-d6 (D, 98%) |
| DLM-9RG* | Acetone-d6 (D, 99.5%) |
| DLM-247 | Acetyl chloride-d3 (D, 98%) |
| DLM-855 | Acrylic-2,3,3-d3 acid (+ 0.1% 4-methoxyphenol) (D, 98%) (<5% H2O) |
| DLM-710RG | Ammonium deuteroxide-d5 (D, 99%) (~25% sol. in D2O) |
| DLM-862 | Aniline-ring-d5 (D, 98%) |
| DLM-1RG* | Benzene-d6 (D, 99%) |
| DLM-494 | Biphenyl-d10 (D, 98%) |
| DLM-1315 | Borane-d3 (D, 98%) (1 molar in THF) (+0.005M NaBD4) |
| DLM-4747 | Borane-d3 methylsulfide complex (D, 98%) (contains <10% additional dimethylsulfide) |
| DLM-398 | Bromobenzene-d5 (D, 99%) |
| DLM-874 | Bromoethane-d5 (D, 98%) |
| DLM-181 | 1,4-Butanediol-2,2,3,3-d4 (D, 98%) |
| DLM-1664 | tert-Butanol-d10 (D, 98%) |
| DLM-1116 | tert-Butyl chloride-d9 (D, 98%) |
| DLM-263 | Chlorobenzene-d5 (D, 99%) |
| DLM-337 | Chlorobenzene-d3 (D, 99%) |
| DLM-7RG | Chloroform-d (D, 99.7%) |
| DLM-1560 | Cyclohexanone-d10 (D, 98%) |
| DLM-2781 | Cyclopentyl bromide-d9 (D, 98%) |
| DLM-1003DR | Deuterium (D, 99.96%) <400 ppm HD |
| DLM-408DR | Deuterium (D, 99.8%) (D2, 99.6% + HD, 0.4%) |
| DLM-458DR | Deuterium chloride (D, 99%) |
| DLM-3DR | Deuterium chloride (D, 99.5%) DCl 35% w/w solution in D2O |
| DLM-2 | Deuterium chloride (D, 99.5%) DCl 20% w/w solution in D2O |
| DLM-4DR | Deuterium oxide (D, 99.9%) |
| DLM-4DR-99.8 | Deuterium oxide (D, 99.8%) |
| DLM-195 | 1,2-Dibromoethane-d4 (D, 99%) |
| DLM-158 | 1,2-Dichlorobenzene-d4 (D, 99%) |
| DLM-265 | Dimethyl-d6-amine:HCl (D, 98%) |
| DLM-3903 | Dimethyl carbonate-d6 (D, 99%) |
| DLM-196 | Dimethyl sulfate-d6 (D, 98%) |
| DLM-10RG* | Dimethyl sulfoxide-d6 (D, 99.9%) |
| DLM-25 | N,N-Dimethylformamide-d7 (D, 99.5%) |
| DLM-1670 | N,N-Dimethylformamide (formyl-D, 98-99%) |
| DLM-31 | Ethanol-d6 (D, 99%) anhydrous |
| DLM-16 | Ethanol-OD (D, 99%) <6% D2O |
| DLM-9660 | N-Ethylaniline-d10 (D, 98%) |
| DLM-9626 | N-Ethyl-d5-aniline (D, 98%) |
| DLM-347 | Ethylene-d4 (D, 98%) |
| DLM-805 | Formaldehyde-d2 (D, 98%) (~20% w/w in D2O) |
| DLM-286 | Formic acid-d2 (D, 98%) (<5% D2O) |
| DLM-743 | Formic acid (formyl-D, 98%) (<5% H2O) |
| DLM-423 | n-Heptane-d16 (D, 98%) |
| DLM-1023 | Iodoethane-1,1-d2 (D, 98%) + copper wire |
| DLM-1024 | Iodoethane-2,2,2-d3 (D, 98%) + copper wire |
| DLM-272 | Iodoethane-d5 (D, 99%) + copper wire |
| DLM-44 | Isopropanol-d8 (D, 99%) |
| DLM-6201 | α-Ketoglutaric acid-3,3,4,4-d4 (D, 98%) CP 90 |
| DLM-1945 | bis(2-Chloroethoxy)-d8-methane (D, 98%) |
| DLM-1981 | Methanesulfonic acid-d4 (D, 97-98%) |
| DLM-24RG* | Methanol-d4 (D, 99.5%) |
| DLM-15 | Methanol-OD (D, 99%) |
| DLM-10186 | Methylboronic acid (methyl-D3, 98%) >90% CP |
| DLM-651 | Methyl formate (formyl-D, 99%) |
| DLM-362 | Methyl iodide-d3 (D, 99.5%) + copper wire |
| DLM-9707 | Methyl-d3 methanesulfonate (D, 98%) |
| DLM-1500DR | Methyl-d3-amine (D, 98%) |
| DLM-289 | Methyl-d3-amine·HCl (D, 98%) |
| DLM-23RG | Methylene chloride-d2 (D, 99.8%) |
| DLM-3484 | Morpholine-2,2,3,3,5,5,6,6-d8 (D, 98%) |
| DLM-295 | 2-Nitrophenol-ring-d4 (D, 98%) |
| DLM-296 | 4-Nitrophenol-ring-d4 (D, 98%) |
| DLM-619 | Octanoic acid-d15 (D, 98%) |
| DLM-300 | Paraformaldehyde-d2 (D, 99%) |
| DLM-370 | Phenol-d6 (D, 98%) |
| DLM-788 | Phthalic anhydride-d4 (D, 98%) |
| DLM-9813 | Pivalic acid-trimethyl-d9 (D, 98%) |
| DLM-9662 | Pyrrolidine-2,2,3,3,4,4,5,5-d8 (D, 98%) |
| DLM-3078DR | N-Propanol-d7 (D, 98%) |
| DLM-226 | Sodium borodeuteride-d4 (D, 99%) CP 90-95% |
| DLM-45DR | Sodium deuteroxide (D, 99.5%) 40% in D2O |
| DLM-1361 | Sodium formate (D, 98%) |
| DLM-8206 | Sodium 2,2-dimethyl-2-silapentane-5-sulfonate-d6 (DSS) (D, 98%) |
| DLM-33DR | Sulfuric acid-d2 (D, 99%) 96-98% in D2O |
| DLM-36 | Tetrahydrofuran-d8 (D, 99.5%) |
| DLM-2729 | Tetramethylsilane-d12 (D, 98%) |
| DLM-5RG* | Toluene-d8 (D, 99.5%) |
| DLM-46RG* | Trifluoroacetic acid-d (D, 98%) |
*Reagent grade — CP = chemical purity
References
- Faleb, E.; Ulanenko, K.; et al. 2017. A Highly Efficient Suzuki-Miyaura Methylation of Pyridines Leading to the Drug Pirfenidone and to its CD3 Version (SD-560), Green Chemistry — Read article
- Hamilton, P. 2017. Deuterated drugs are new chemical entities. JDSUPRA® — Read article
- Mullard, A. 2016. Deuterated drugs draw heavier backing. Nature Reviews Drug Discovery, published online 1 Apr 2016, PMID: 27032821
- 2015. Drugs that live long will prosper. The Economist, Science & Technology, Sept. 5 edition — Read article
Technical product information
