Membrane Proteins
Membrane proteins make up between 20% and 30% of all expressed proteins and represent more than half of all present-day drug targets. Generally, membrane proteins have hydrophobic exteriors, are relatively dynamic, and are expressed at relatively low levels. These factors create difficulties in obtaining stable preparations for NMR analyses.
Fortunately, there are many sample preparation conditions that can be chosen for solution and solid state NMR. Most preparations require solubilization within a lipid bilayer.
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