Mass Spectrometry & Analytics
Stable isotope-labeled internal standards for accurate, reproducible quantification by mass spectrometry
Isotope-dilution mass spectrometry (IDMS) is one of the most accurate, sensitive, and reproducible methods available for quantifying small and intermediate-sized molecules across a wide range of sample types. Compounds enriched in stable isotopes make ideal internal standards, as they share nearly identical chemical behavior with the analyte of interest while remaining distinguishable by mass.
By adding a known amount of an isotopically labeled internal standard to a sample, researchers can correct for losses, matrix effects, and instrument drift that would otherwise compromise accuracy. This approach is widely used across clinical diagnostics, newborn screening, environmental testing, food safety, and pharmaceutical research, wherever precise quantification of trace-level compounds is required.
Why Isotope Dilution Mass Spectrometry
- Accuracy — corrects for matrix effects, analyte loss, and instrument drift by tracking a known isotopic spike alongside the analyte.
- Reproducibility — labeled standards behave near-identically to the analyte during extraction, separation, and ionization.
- Broad applicability — used in clinical diagnostics, newborn screening, food and environmental testing, and pharmaceutical development.
- Trace-level sensitivity — enables reliable quantification even at very low analyte concentrations.
Related Applications
Clinical Mass Spectrometry
Stable isotope-labeled standards supporting mass spectrometry across clinical diagnostics
MS/MS Screening Standards and Mixes
Class-specific standards and mixes for MS/MS screening and IDMS quantification
Trace Element Analysis
Isotopically enriched elements for trace-level detection by ICP-MS
